![]() ![]() #The next big thing 2017 series#The "Focus on extracellular vesicles" series of reviews highlights the current state of the art regarding various topics in EV research, whilst this review serves as an introductory overview of EVs, their biogenesis and molecular composition.Īpoptotic body biogenesis ectosome exosome extracellular vesicle isolation microvesicle molecular composition signal transduction. Consequently, the research effort into the pathogenic roles of EVs is significantly higher even though their protective roles are not well established. Additionally, it is now becoming increasingly clear that EVs mediate disease progression and therefore studying EVs has ignited significant interests among researchers from various fields of life sciences. Whilst this is a major function of one type of EV, i.e., apoptotic bodies, many EVs have intricate functions in intercellular communication and compound exchange although their physiological roles are still ill-defined. ![]() These "extracellular vesicles" (EV) were initially thought to be garbage bags through which the cell ejected its waste. With the discovery of small secreted vesicular structures that contain complex cargo, both in their lumen and the lipid membrane that surrounds them, a new frontier of signal transduction was discovered. You could get a book and have a good time.Intercellular communication was long thought to be regulated exclusively through direct contact between cells or via release of soluble molecules that transmit the signal by binding to a suitable receptor on the target cell, and/or via uptake into that cell. I’m looking forward to reading stories by some of my favorites and discovering good work from more people I don’t yet know.Ĭonsider a pledge today and you could find the same kind of fun. There are lots of cool perks you can get, and lots of good you can do by chipping in to make this book happen. The Mine! campaign runs for one more week. People would not be able to plan parenthood, one of the most important decisions a person can make. They wouldn’t be able to get pre-natal and post-natal care. Poor women and women without insurance (which might be all of us, if the GOP has its way) wouldn’t be able to get mammograms or other kinds of cancer screenings. Obviously, a huge chunk of the comics community agrees with me, because so many are contributing work to Mine! They know that, without Planned Parenthood, millions of people wouldn’t be able to get tested (and treated, if necessary) for STDs. As part of the marketplace, I enjoy more choices.Īs someone of a certain age, I don’t like being passed over for someone who will work for less money.īeing of that age, I’m also really worried about having access to affordable health care. They can sign new talent for less than they pay more experienced workers, and they can offer something shiny and new to the marketplace. There are financial incentives to those publishers (and producers, and manufacturers) who are first to find the Next Big Thing, or at least the Flavor of the Month. There are some downsides to this, and I blame capitalism. And new generations of artists are always being born, always working to create work that is meaningful to them, and to their peers. It’s easier to find than ever before, even when it was new. The entertainment (and art!) that I loved is still available to me. ![]() The angry young men (and women) of my punk rock days are now old cranks if they survived. Rock’n’roll is barely even a thing anymore. #The next big thing 2017 movie#All of the people I would cast in a movie about the Teen Titans are no longer teenagers.ĭon’t even start me on popular music. ![]() Christina Ricci is Wednesday Addams, not a grown-up with breasts. To me, Keanu Reeves is a young time-traveler, not a 53-year old man. Movie actors have a tendency to age as well. This is because I am old and stuck in my ways, and even when I try to keep up, time passes. And Dave Kelly and Lara Antal.Īll of these people do amazing work. In addition to talents like Neil Gaiman and Jill Thompson, there are a bunch of people whom I know personally on the list but there are also a whole lot I don’t know.įor example, there’s Gabby Rivera. I am reminded of this when I look at the list of contributors to Mine! A Comics Collection to Benefit Planned Parenthood. How was it discovered? Why are units of time, like minutes and hours and days, all measured in multiples of 6? What was there before time? Could time ever end? If so, what would replace it? Eventually, these thoughts made me throw up, and I would have to make myself think about other stuff.īut here’s the thing: Time happens. When I was a child, I was mesmerized by the very concept of time. ![]()
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